Characterization of Triple | 中藥處方小百科

由ZHuang著作·2020·被引用11次—SpheroidformationbyMDA-MB-231cellsisattributedtothenon-adherentcultureconditions,highdegreeofconfluenceandnutrient/oxygen ...

Breast cancer (BC) has post a major threat to female health worldwide, and its morbidity shows an increasing trend year by year.1 Recent statistical data suggest that, 40% BC patients still develop distant metastasis (DM) after standardized treatment, which eventually leads to death.2 Metastasis represents the fundamental feature of malignant tumor, which is associated with very complex mechanism.

Traditionally, the mechanisms of metastatic BC progression have been widely studied in the in vitro two-dimensional (2D) cultures by exposure to external stimulus and in xenograft models by manipulating various signaling pathways and molecular targets.3,4 However, these do not represent the native events of BC progression. Three-dimensional (3D) culture systems provide unique opportunities to culture cancer cells alone or in combination with other cell types in a spatially relevant m...